Human Recombinant FGF-7, ACF

Fibroblast growth factor 7, animal component-free
Catalog #
78186_C
Fibroblast growth factor 7, animal component-free
From: 1,117 USD

Overview

Fibroblast growth factor 7 (FGF-7) is a member of the FGF family, and acts exclusively through a subset of FGF receptor isoforms expressed predominantly by epithelial cells (Finch & Rubin). FGF-7 seems to act specifically on epithelial cells and stimulates proliferation, migration, and differentiation of these cells, and also participates in epithelial protection and repair both in vitro and in vivo (Finch & Rubin; Werner). In contrast, FGF-7 is produced solely by cells of mesenchymal origin, and functions as a paracrine mediator of mesenchymal-epithelial communication (Rubin et al.). FGF-7 has also been shown to supplement several wound-healing properties of bioengineered skin (Erdag et al.) and to induce autophagy in human keratinocytes (Belleudi et al.). Additionally, FGF-7 has a role in the differentiation of pluripotent stem cell to endodermal pancreatic-like insulin-producing cells and thymic epithelial cells (Inami et al.; Niu et al.). This product is animal component-free.
Subtype
Cytokines, Growth Factors
Alternative Names
Fibroblast growth factor 7, HBGF-7, Heparin-binding growth factor 7, Keratinocyte growth factor, KGF
Cell Type
Endoderm, PSC-Derived, Hematopoietic Stem and Progenitor Cells, Keratinocytes, Mammary Cells, Mesenchymal Stem and Progenitor Cells, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Pluripotent Stem Cells, Prostate Cells
Species
Human
Area of Interest
Epithelial Cell Biology, Neuroscience, Stem Cell Biology
Molecular Weight
19.0 kDa
Purity
≥ 90%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant FGF-7, ACF
Catalog #
78186.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant FGF-7, ACF
Catalog #
78186.1
Lot #
All
Language
English

Educational Materials(4)

Brochure
Cytokines, Chemokines and Growth Factors
Brochure
Reliable Antibodies for Your Research
Wallchart
Directed Differentiation of Pluripotent Stem Cells
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research

Data and Publications

Data

(A) The biological activity of Human Recombinant FGF-7, ACF was tested by its ability to promote proliferation of 4MBr-5 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 2.5 ng/mL. (B) 1 μg of Human Recombinant FGF-7, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-7, ACF has a predicted molecular mass of 19.0 kDa.

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