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Small Molecules

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CHIR99021

WNT pathway activator; Inhibits GSK3
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Y-27632

RHO/ROCK pathway inhibitor; Inhibits ROCK1 and ROCK2
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(+)-Bay K8644

L-type calcium channel inhibitor
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(-)-Blebbistatin

Non-muscle myosin II (NM II) ATPase inhibitor
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(-)-Epigallocatechin Gallate

Antioxidant and epigenetic modifier; Inhibits DNA methyltransferases (DNMTs)
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(-)-Indolactam V

Protein kinase C (PKC) activator
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(2R)-Octyl-α-hydroxyglutarate

Inhibits α-ketoglutarate-dependent dioxygenases
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(S)-MG132

Ubiquitin-proteasome inhibitor; NF-kB pathway inhibitor; IκB activator
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(Z)-4-Hydroxytamoxifen

Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor
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(Z)-Guggulsterone

Retinoic acid receptor (RAR) pathway inhibitor; Inhibits farnesoid X receptor (FXR)
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(±)-Flurbiprofen

PI3K/AKT pathway inhibitor; Inhibits COX-1 and COX-2
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(±)-Nutlin-3

p53 pathway activator; Inhibits MDM2