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Small Molecules

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(±)-Nutlin-3

p53 pathway activator; Inhibits MDM2
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1-Oleoyl Lysophosphatidic Acid

Lysophosphatidic acid (LPA)1 and LPA2 agonist
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16,16-Dimethyl Prostaglandin E2

Prostanoid pathway activator; Inhibits 15-hydroxy PGDH
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3-Deazaneplanocin A

Epigenetic modifier; Inhibits histone EZH2 lysine methyltransferase
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5-Azacytidine

Epigenetic modifier; Inhibits DNA methyltransferase (DNMT)
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8-Bromo-cAMP

cAMP pathway activator; Activates cAMP-dependent kinase
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9-cis Retinoic Acid

Retinoid pathway activator; Activates retinoic acid receptor (RAR) and retinoid X receptor (RXR)
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A 83-01

Activin/NODAL/TGF-β pathway inhibitor; Inhibits ALK5, ALK4, and ALK7
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A769662

AMPK activator
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AG-490

Tyrosine kinase inhibitor; Inhibits EGFR, HER2, JAK2, JAK3 and STAT5a/b
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AGK2

Epigenetic modifier; Inhibits SIRT2 histone deacetylase
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AKT Inhibitor VIII

PI3K/AKT pathway inhibitor; Inhibits AKT1, AKT2, AKT3