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Mesenchymal Stem and Progenitor Cell Research

MSCs, originally coined mesenchymal stem cells1 but now also referred to by other terms, such as multipotent mesenchymal stromal cells,2,3 mesenchymal progenitor cells4 or medicinal signaling cells,5 occur at low frequency in tissues and must be expanded in vitro to obtain sufficient numbers for basic and translational research. See More

Serum-containing (for human and mouse cells) and serum-free (for human cells) MesenCult™ media are optimized for efficient expansion of MSCs in culture and the quantification of functional MSCs in the colony-forming unit - fibroblast (CFU-F) assay. With standardized, xeno-free and animal component-free media formulations available, concerns about immune rejection of transplanted cells or disease transmission are addressed.6

References

  1. Caplan AI et al. (1991) J Orthop Res 9(5): 641-650
  2. Horwitz EM et al. (2005) Cytotherapy 7(5) 393-5
  3. Dominici M et al. (2006) Cytotherapy 8(4) 315-7
  4. Shenaq DS. et al. (2010) Stem Cells Int doi: 10.4061/2010/519028
  5. Caplan AI. (2010) Tissue Eng Part A 16(8) 2415-7
  6. Thirumala S et al. (2013) Expert Opin Biol Ther 13(5): 673-91
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