Bafilomycin A1
Inhibits autophagy and vacuolar H+-ATPase (V-ATPase)
Overview
Bafilomycin A1 is a macrolide antibiotic drug and autophagy inhibitor. It prevents the acidification of autophagosomes via the inhibition of vacuolar H+-ATPase (V-ATPase; Klionsky et al.).
MAINTENANCE AND SELF-RENEWAL
· Inhibits the proteolytic degradation associated with autophagy in human mesenchymal stem cells (Oliver et al.).
CANCER RESEARCH
· At low concentrations, it inhibits autophagy and promotes apoptotic cell death in pediatric B cell acute lymphoblastic leukemia (B-ALL) cells (Yuan et al.).
MAINTENANCE AND SELF-RENEWAL
· Inhibits the proteolytic degradation associated with autophagy in human mesenchymal stem cells (Oliver et al.).
CANCER RESEARCH
· At low concentrations, it inhibits autophagy and promotes apoptotic cell death in pediatric B cell acute lymphoblastic leukemia (B-ALL) cells (Yuan et al.).
Alternative Names
NSC 381866
Cell Type
B Cells, Cancer Cells and Cell Lines, Leukemia/Lymphoma Cells, Mesenchymal Stem and Progenitor Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Maintenance
Area of Interest
Autophagy, Cancer, Immunology, Stem Cell Biology
CAS Number
88899-55-2
Chemical Formula
C₃₅H₅₈O₉
Molecular Weight
622.8 g/mol
Purity
≥ 95%
Related Products
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Scientific Resources
Product Documentation
| Document Type | Product Name | Catalog # | Lot # | Language |
|---|---|---|---|---|
|
Document Type
Product Information Sheet
|
Product Name
Bafilomycin A1
|
Catalog #
74242 |
Lot #
All |
Language
English |
|
Document Type
Safety Data Sheet
|
Product Name
Bafilomycin A1
|
Catalog #
74242 |
Lot #
All |
Language
English |
Educational Materials (3)
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Mini Review
Small Molecules
Product Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
