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Bafilomycin A1

Inhibits autophagy and vacuolar H+-ATPase (V-ATPase)

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Bafilomycin A1

Inhibits autophagy and vacuolar H+-ATPase (V-ATPase)

From: 523 USD
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Inhibits autophagy and vacuolar H+-ATPase (V-ATPase)
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Overview

Bafilomycin A1 is a macrolide antibiotic drug and autophagy inhibitor. It prevents the acidification of autophagosomes via the inhibition of vacuolar H+-ATPase (V-ATPase; Klionsky et al.).


MAINTENANCE AND SELF-RENEWAL
· Inhibits the proteolytic degradation associated with autophagy in human mesenchymal stem cells (Oliver et al.).

CANCER RESEARCH
· At low concentrations, it inhibits autophagy and promotes apoptotic cell death in pediatric B cell acute lymphoblastic leukemia (B-ALL) cells (Yuan et al.).
Cell Type
B Cells, Cancer Cells and Cell Lines, Leukemia/Lymphoma Cells, Mesenchymal Stem and Progenitor Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Maintenance
Area of Interest
Autophagy, Cancer, Immunology, Stem Cell Biology
CAS Number
88899-55-2
Chemical Formula
C₃₅H₅₈O₉
Purity
≥ 95%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Bafilomycin A1
Catalog #
74242
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Bafilomycin A1
Catalog #
74242
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (3)

Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Small Molecules, Big Impact in Cancer Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Small Molecules
Mini Review
Small Molecules

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Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.

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