Bafilomycin A1

Inhibits autophagy and vacuolar H+-ATPase (V-ATPase)
Bafilomycin A1

Inhibits autophagy and vacuolar H+-ATPase (V-ATPase)

500 µg
Catalog # 74242
441 USD

Overview

Bafilomycin A1 is a macrolide antibiotic drug and autophagy inhibitor. It prevents the acidification of autophagosomes via the inhibition of vacuolar H+-ATPase (V-ATPase; Klionsky et al.).


MAINTENANCE AND SELF-RENEWAL
· Inhibits the proteolytic degradation associated with autophagy in human mesenchymal stem cells (Oliver et al.).

CANCER RESEARCH
· At low concentrations, it inhibits autophagy and promotes apoptotic cell death in pediatric B cell acute lymphoblastic leukemia (B-ALL) cells (Yuan et al.).
Alternative Names
NSC 381866
Cell Type
B Cells, Cancer Cells and Cell Lines, Leukemia/Lymphoma Cells, Mesenchymal Stem and Progenitor Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Maintenance
Area of Interest
Autophagy, Cancer, Immunology, Stem Cell Biology
CAS Number
88899-55-2
Chemical Formula
C₃₅H₅₈O₉
Molecular Weight
622.8 g/mol
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Bafilomycin A1
Catalog #
74242
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Bafilomycin A1
Catalog #
74242
Lot #
All
Language
English

Educational Materials (5)

Brochure
Small Molecules for Stem Cell Research
Brochure
Small Molecules for Cancer Research
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Mini Review
Small Molecules

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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