SMER28

Enhances mammalian autophagy
Catalog #
74202_C
Enhances mammalian autophagy
From: 61 USD

Overview

SMER28, a bromo-substituted quinazoline, was first identified as a small-molecule enhancer of rapamycin (SMER; Sarkar et al.). SMER28 induces autophagy by increasing autophagosome synthesis and enhancing the clearance of model autophagy substrates (Renna et al.).


REPROGRAMMING
· As a component of a neural reprogramming cocktail, SMER28 reprograms mouse fibroblasts into induced neural stem cell-like cells (Zhang et al.).

DISEASE MODELING
· Enhances clearance of autophagy substrates including mutant huntingtin in Huntington's disease and A53T α-synuclein in familial Parkinson's disease (Sarkar et al.).
· Through autophagy factor ATG5, stimulates erythropoiesis and up-regulates expression of globin genes in both in vitro and in vivo models of Diamond-Blackfan anemia (Doulatov et al.).
· Decreases the level of indicators of Alzheimer's disease (amyloid-β peptide and the amyloid precursor protein [APP]-derived fragment) via the autophagy-related protein 5-dependent pathway (Tian et al.).
Alternative Names
Not applicable
Cell Type
Erythroid Cells, Hematopoietic Stem and Progenitor Cells, Mouse Embryonic Fibroblasts, Neural Stem and Progenitor Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Reprogramming
Area of Interest
Autophagy, Disease Modeling, Neuroscience, Stem Cell Biology
CAS Number
307538-42-7
Chemical Formula
C₁₁H₁₀BrN₃
Molecular Weight
264.1 g/mol
Purity
≥ 98%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
SMER28
Catalog #
74202, 74204
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
SMER28
Catalog #
74202, 74204
Lot #
All
Language
English

Educational Materials (3)

Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Mini Review
Small Molecules

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Contact STEMCELL Technologies

Our Customer Service, Sales, and Product and Scientific Support departments in North America are available between 6 am and 5 pm Pacific Time (9 am and 8 pm Eastern Time). One of our representatives will be happy to help you by telephone or email. Please complete the form to contact us by email. A representative will get back to you shortly.
  •  

StemCell Technologies Inc. and affiliates ("STEMCELL Technologies") does not share your email address with third parties. StemCell Technologies Inc. will use your email address to confirm your identity and send you newsletters, transaction-related emails, promotional and customer service emails in accordance with our privacy policy. You can change your email preferences at any time.