Human Recombinant FGF-7, ACF

Fibroblast growth factor 7, animal component-free

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Fibroblast growth factor 7, animal component-free
From: 207 USD

Overview

Fibroblast growth factor 7 (FGF-7) is a member of the FGF family, and acts exclusively through a subset of FGF receptor isoforms expressed predominantly by epithelial cells (Finch & Rubin). FGF-7 seems to act specifically on epithelial cells and stimulates proliferation, migration, and differentiation of these cells, and also participates in epithelial protection and repair both in vitro and in vivo (Finch & Rubin; Werner). In contrast, FGF-7 is produced solely by cells of mesenchymal origin, and functions as a paracrine mediator of mesenchymal-epithelial communication (Rubin et al.). FGF-7 has also been shown to supplement several wound-healing properties of bioengineered skin (Erdag et al.) and to induce autophagy in human keratinocytes (Belleudi et al.). Additionally, FGF-7 has a role in the differentiation of pluripotent stem cell to endodermal pancreatic-like insulin-producing cells and thymic epithelial cells (Inami et al.; Niu et al.). This product is animal component-free.
Alternative Names:
Fibroblast growth factor 7, HBGF-7, Heparin-binding growth factor 7, Keratinocyte growth factor, KGF
Cell Type:
Endoderm, PSC-Derived; Hematopoietic Stem and Progenitor Cells; Keratinocytes; Mammary Cells; Mesenchymal Stem and Progenitor Cells; Neural Cells, PSC-Derived; Neural Stem and Progenitor Cells; Pluripotent Stem Cells; Prostate Cells
Species:
Human
Area of Interest:
Epithelial Cell Biology; Neuroscience; Stem Cell Biology
Molecular Weight:
19.0 kDa
Purity:
≥ 90%

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Data

(A) The biological activity of Human Recombinant FGF-7, ACF was tested by its ability to promote proliferation of 4MBr-5 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 2.5 ng/mL. (B) 1 μg of Human Recombinant FGF-7, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-7, ACF has a predicted molecular mass of 19.0 kDa.

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