Human Recombinant FGF-10 (KGF-2), ACF

Fibroblast growth factor 10, animal component-free
Catalog #
78173_C
Fibroblast growth factor 10, animal component-free
From: 433 GBP

Overview

Fibroblast growth factor 10 (FGF-10) is a member of the fibroblast growth factor (FGF) family which is predominantly expressed by mesenchymal fibroblasts during embryonic development (Emoto et al.; Igarashi et al.). It binds with high affinity to fibroblast growth factor receptor 2-IIIb (FGFR2-IIIb), and also has a weaker affinity for FGFR1-IIIb (Beer et al.). FGF-10 and FGF-7 have similar receptor binding properties and target cell specificities but are differentially regulated by components of the extracellular matrix (Emoto et al.; Igarashi et al.). FGF-10 has been shown to mediate epithelial-mesenchymal interactions, which are essential to lung development (Sekine et al.; Ware & Matthay). FGF-10 also has a role in mobilization and proliferation of lung-resident mesenchymal stem cells (MSCs) and protection and repair against acute lung injury (Tong et al.; Ware & Matthay) and endodermal differentiation of human pluripotent stem cells to insulin-producing pancreatic-like cells (Takeuchi et al.). This product is animal component-free.
Subtype
Cytokines, Growth Factors
Alternative Names
Fibroblast growth factor 10, Keratinocyte growth factor 2
Cell Type
Endoderm, PSC-Derived, Hematopoietic Stem and Progenitor Cells, Keratinocytes, Mesenchymal Stem and Progenitor Cells, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Pluripotent Stem Cells, Prostate Cells
Species
Human
Area of Interest
Epithelial Cell Biology, Neuroscience, Stem Cell Biology
Molecular Weight
19.3 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant FGF-10 (KGF-2), ACF
Catalog #
78173.1, 78173.2
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant FGF-10 (KGF-2), ACF
Catalog #
78173.1, 78173.2
Lot #
All
Language
English

Educational Materials (5)

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Scientific Poster
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Data and Publications

Data

(A) The biological activity of Human Recombinant FGF-10 (KGF-2), ACF was tested by its ability to promote proliferation of 4MBr-5 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 6.45 ng/mL. (B) 1 μg of Human Recombinant FGF-10 (KGF-2), ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-10 (KGF-2), ACF has a predicted molecular mass of 19.3 kDa.

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