Human Recombinant PDGF-CC

Platelet-derived growth factor CC
Catalog #
78168_C
Platelet-derived growth factor CC
From: 105 USD

Overview

The platelet-derived growth factor (PDGF) family has five heparin-binding members that assemble into four homodimers (PDGF-AA, PDGF-BB, PDGF-CC, and PDGF-DD) and one heterodimer (PDGF-AB; Li & Eriksson). PDGF signals through the receptor tyrosine kinases PDGFRα and PDGFRβ. It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src and PI3K/AKT (Kim et al.). PDGF is a potent mitogen for cells of mesenchymal origin such as fibroblasts and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues (Fretto et al.; Sachinidis et al.). PDGF-CC is secreted as a latent growth factor and requires activation by proteolytic processing (Li & Eriksson). PDGF-CC binds to PDGFRα homodimers and PDGFRαβ heterodimers, but not to PDGFRβ homodimers (Li & Eriksson). PDGF-CC is an angiogenic factor that stimulates coronary artery smooth muscle cell proliferation and plays a role in cardiovascular development (Gilbertson et al.). PDGF-CC is also expressed in many tumors and plays a role in tumorigenesis (Zwerner & May).
Subtype
Cytokines, Growth Factors
Alternative Names
PDGF, Platelet-derived growth factor
Cell Type
Mesenchymal Cells, PSC-Derived, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Neurons, Osteoblasts, Other
Species
Human
Area of Interest
Neuroscience, Stem Cell Biology
Molecular Weight
12.5 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant PDGF-CC
Catalog #
78168
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant PDGF-CC
Catalog #
78168
Lot #
All
Language
English

Educational Materials (7)

Brochure
Reliable Antibodies for Your Research
Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
The Identity and Properties of Mesenchymal Stem Cells
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Cell-Reprogramming Technology and Neuroscience
Wallchart
Small Molecules, Big Impact in Cancer Research
Wallchart
Directed Differentiation of Pluripotent Stem Cells

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant PDGF-CC was tested by its ability to promote the proliferation of 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 1 ng/mL. (B) 5 μg of Human Recombinant PDGF-CC was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant PDGF-CC has a predicted molecular mass of 12.5 kDa.

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