Human Recombinant FGF-18

Fibroblast growth factor 18

Human Recombinant FGF-18

Fibroblast growth factor 18

From: 108 USD
Catalog #
78041_C
Fibroblast growth factor 18

Overview

Fibroblast growth factor 18 (FGF-18) is a growth factor and member of the FGF subfamily. FGF-18 is most similar to FGF-8 and FGF-17, and is secreted in adult lung and developing tissues (Ohbayashi et al.). FGF-18 signals through FGF receptor 3 (FGFR3) to regulate proliferation, differentiation, and matrix production of articular and growth plate chondrocytes in vivo and in vitro (Davidson et al.). FGF-18 has skeletal functions and protects articular cartilage by gene expression profiling and regulates proliferation and differentiation of midline cerebellar structures (Mori et al.). Also, recombinant human FGF-18 has been shown to effectively regulate hair growth (Song et al.).
Subtype
Cytokines, Growth Factors
Alternative Names
FGFI, Fibroblast growth factor-18, zFGF5
Cell Type
Endoderm, PSC-Derived, Hematopoietic Stem and Progenitor Cells, Mammary Cells, Mesenchymal Stem and Progenitor Cells, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Pluripotent Stem Cells, Prostate Cells
Species
Human
Area of Interest
Epithelial Cell Biology, Neuroscience, Stem Cell Biology
Molecular Weight
20.3 kDa
Purity
≥ 95 %

Data Figures

(A) The biological activity of Human Recombinant FGF-18 was tested by its ability to promote the proliferation of BALB/c 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 10 ng/mL. (B) 2 μg of Human Recombinant FGF-18 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-18 has a predicted molecular mass of 20.3 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78041
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78041
Lot #
All
Language
English

Resources and Publications

Educational Materials (1)

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