Human Recombinant FGF-4

Fibroblast growth factor 4
Catalog #
78103_C
Fibroblast growth factor 4
From: 185 USD

Overview

Fibroblast growth factor 4 (FGF-4) is a member of the FGF superfamily (Beenken & Mohammadi). FGF-4 is expressed in pluripotent stem cells and is implicated in various stages of development and morphogenesis in a variety of organisms (Kosaka et al. 2009). FGF-4 has been shown to have an ability to promote neural stem cell proliferation and neuronal differentiation in the postnatal brain (Kosaka et al. 2006). FGF-4 has also been shown to increase the proliferation rate of mesenchymal stem cells (Farré et al.). FGF-4 supports the maintenance and self-renewal properties of human embryonic stem cells and also promotes the proliferation of these cells (Mayshar et al.). In the mouse, the Fgf4 gene also supports proliferation of the inner cell mass (ICM) and postimplantation embryos (Feldman et al.).
Subtype
Cytokines, Growth Factors
Alternative Names
HBGF-4, Heparin-binding growth factor 4, Heparin secretory transforming protein 1, HST, HST-1, HSTF-1, Kaposi sarcoma oncogene, KFGF, Transforming protein KS3
Cell Type
Endoderm, PSC-Derived, Hematopoietic Stem and Progenitor Cells, Keratinocytes, Mammary Cells, Mesenchymal Stem and Progenitor Cells, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Pluripotent Stem Cells, Prostate Cells
Species
Human
Area of Interest
Epithelial Cell Biology, Neuroscience, Stem Cell Biology
Molecular Weight
19.4 kDa
Purity
≥ 95 %

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant FGF-4
Catalog #
78103.1, 78103.2
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant FGF-4
Catalog #
78103.1, 78103.2
Lot #
All
Language
English

Educational Materials (2)

Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
Directed Differentiation of Pluripotent Stem Cells

Data and Publications

Data

(A) The biological activity of Human Recombinant FGF-4 was tested by its ability to promote the proliferation of BALB/c 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.5 ng/mL. (B) 2 μg of Human Recombinant FGF-4 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-4 has a predicted molecular mass of 19.4 kDa.

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