Human Recombinant FGF-10 (KGF-2)

Fibroblast growth factor 10

Human Recombinant FGF-10 (KGF-2)

Fibroblast growth factor 10

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Fibroblast growth factor 10
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Overview

Fibroblast growth factor 10 (FGF-10) is a member of the fibroblast growth factor (FGF) family predominantly expressed by mesenchymal fibroblasts during embryonic development (Emoto et al.; Igarashi et al.). It binds with high affinity to fibroblast growth factor receptor 2-IIIb (FGFR2-IIIb), and also has a weaker affinity for FGFR1-IIIb (Beer et al.). FGF-10 and FGF-7 have similar receptor binding properties and target cell specificities but are differentially regulated by components of the extracellular matrix (Emoto et al.; Igarashi et al.). FGF-10 has been shown to mediate epithelial-mesenchymal interactions, which are essential to lung development (Sekine et al; Ware & Matthay). FGF-10 also has a role in mobilization and proliferation of lung-resident mesenchymal stem cells (MSCs) and protection and repair against acute lung injury (Tong et al.; Ware & Matthay), as well as endodermal differentiation of human pluripotent stem cells to insulin-producing pancreatic-like cells (Takeuchi et al.).
Subtype
Cytokines, Growth Factors
Cell Type
Endoderm, PSC-Derived, Hematopoietic Stem and Progenitor Cells, Keratinocytes, Mammary Cells, Mesenchymal Stem and Progenitor Cells, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Pluripotent Stem Cells, Prostate Cells
Species
Human
Area of Interest
Epithelial Cell Biology, Neuroscience, Stem Cell Biology
Purity
≥ 95%

Data Figures

(A) The biological activity of Human Recombinant FGF-10 (KGF-2) was tested by its ability to promote the proliferation of 4MBr-5 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 20 ng/mL. (B) 2 μg of Human Recombinant FGF-10 (KGF-2) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-10 (KGF-2) has a predicted molecular mass of 19.3 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78037.1, 78037.2, 78037, 78037.3
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78037.1, 78037.2, 78037, 78037.3
Lot #
All
Language
English

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