Human Pluripotent Stem Cell Research

Induced pluripotent stem (iPS) cells are a type of pluripotent stem cell (PSC) that can be obtained by reprogramming somatic cells through artificial expression of key transcription factors under specific culture conditions.1-2 See More Variables that affect reprogramming include the delivery method, culture conditions and starting cell type. The choice of starting cell type is influenced by factors such as availability of donor tissue, invasiveness of sample collection procedures, genomic integrity, epigenetic memory and reprogramming efficiency. For efficient reprogramming, use our non-viral and non-integrating vector system , TeSR-based media, and small molecules. For blood-derived cells, we offer integrated kits to enrich, isolate, expand and reprogram erythroid progenitor or CD34+ progenitor cells. For help with your hPSC workflow decision making, use our infographics to find the right reagents for you.

References

  1. Takahashi K, et al. Cell 131(5): 861–72, 2007
  2. Yu J, et al. Science 318(5858): 1917–20, 2007
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Products

Cell Culture Media and Supplements (47)

Matrices and Substrates (42)

  • Vitronectin XF™

    Vitronectin XF™

    Defined, xeno-free matrix that supports the growth and differentiation of human pluripotent stem cells under serum-free, feeder-free conditions
  • 0.1% Gelatin in Water

    0.1% Gelatin in Water

    Coating for cultureware

Small Molecules (427)

  • Minocycline (Hydrochloride Hydrate)

    Minocycline

    Antibiotic with anti-inflammatory and neuroprotective properties
  • SB431542 (Hydrate)

    SB431542

    Activin/BMP/TGF-β pathway inhibitor; Inhibits ALK4, ALK5, and ALK7
  • CHIR99021

    CHIR99021

    WNT pathway activator; Inhibits GSK3
  • PD0325901

    PD0325901

    MEK/ERK pathway inhibitor; Inhibits MEK

Primary and Cultured Cells (41)

Tissue and Cell Culture Dissociation Reagents (42)

Cell Storage Media (46)

  • CryoStor® CSB

    CryoStor® CSB

    Animal component-free and protein-free cryopreservation formulation
  • mFreSR™ Cryopreservation Medium for PSCs|05855

    mFreSR™

    Serum-free cryopreservation medium for human ES and iPS cells
  • CryoStor® CS2

    CryoStor® CS2

    Animal component-free, defined cryopreservation medium with 2% DMSO
  • CryoStor® CS5

    CryoStor® CS5

    Animal component-free, defined cryopreservation medium with 5% DMSO

Antibodies (47)

Cytokines and Proteins (45)

Cultureware and General Supplies (41)

Cell Isolation Products (43)

Buffers and Solutions (41)

Training and Education (41)

  • PSC Training Course

    Pluripotent Stem Cell Training

    Training to support the culture of hPSCs and their differentiation towards cerebral organoids, intestinal organoids, cardiomyocytes, or hematopoietic progenitors

Uncategorized (41)

  • Quercetin (Hydrate)

    Quercetin

    mTOR, PI3K/AKT, NF-kB, and tyrosine kinase pathway inhibitor; Inhibits PI3K and SRC kinases

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