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RSC-133

Epigenetic modifier; Inhibits DNA methyltransferase (DNMT)

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RSC-133

Epigenetic modifier; Inhibits DNA methyltransferase (DNMT)

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Epigenetic modifier; Inhibits DNA methyltransferase (DNMT)
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Overview

Reprogramming stimulating compound (RSC)-133 is an indole derivative that specifically inhibits DNA methyltransferase DNMT1 (Lee et al.).

REPROGRAMMING
· Increases kinetics and efficiency of reprogramming human foreskin fibroblasts to induced pluripotent stem cells, when used with reprogramming factors OCT4, SOX2, KLF4, and c-MYC (Lee et al.).

MAINTENANCE & SELF-RENEWAL
· Supports the maintenance of human pluripotent stem cells in unconditioned medium (Lee et al.).
Cell Type
Pluripotent Stem Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Maintenance, Reprogramming
Area of Interest
Stem Cell Biology
CAS Number
1418131-46-0
Chemical Formula
C₁₈H₁₅N₃O₂
Purity
≥ 95%
Pathway
Epigenetic
Target
DNMT

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
RSC-133
Catalog #
73392
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
RSC-133
Catalog #
73392
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (2)

Small Molecules, Big Impact in Cancer Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Small Molecules
Mini Review
Small Molecules

Publications (1)

A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells. Lee J et al. Angewandte Chemie (International ed. in English) 2012

Abstract

Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).
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Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.

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