hPSC-Derived Neural Cell Research

Human pluripotent stem cells (hPSCs), including human embryonic stem cells (ES) cells and induced pluripotent stem cells (iPS) cells are self-renewing cells that have the potential to develop into cells of all three germ layers. See MorehPSCs are a valuable tool for researchers aiming to model human neurological development and disease. By generating iPS cells from patient samples, disease-specific neural stem cells, neurons and glia can be obtained. The first step in your hPSC to neural workflow is the neural induction of hPSCs to generate neural progenitor cells (NPCs). To achieve reproducible and efficient neural induction, use the defined and serum-free STEMdiff™ Neural Induction Medium . This medium is compatible with both embryoid body and monolayer neural induction protocols. The embryoid body protocol utilizes AggreWell™800 plates to form uniform neural aggregates, which, when replated are characterized by the presence of morphologically distinct neural rosette clusters that can be isolated for further experiments using STEMdiff™ Neural Rosette Selection Reagent .

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Whether you’re starting from primary cells, tissue samples, or pluripotent stem cells, explore our complete portfolio of products to support your neural culture workflow.

Products

Cell Culture Media and Supplements (411)

Cell Dyes and Detection Assay Kits (41)

Cell Storage Media (41)

Cultureware and General Supplies (42)

  • AggreWell™800 24-well plate|34811

    AggreWell™800

    Microwell culture plates for easy and reproducible production of embryoid bodies and spheroids
  • 37μm Reversible Strainers|27215,27250

    Reversible Strainers

    Reversible strainer for filtration of single cells and isolation of cellular aggregates, including embryoid bodies and spheroids

Tissue and Cell Culture Dissociation Reagents (43)

Antibodies (41)

Cytokines and Proteins (43)

Small Molecules (410)

  • Dorsomorphin

    Dorsomorphin

    BMP and AMPK pathway inhibitor; Inhibits ALK2, ALK3, ALK6, and AMPK
  • SB431542 (Hydrate)

    SB431542

    Activin/BMP/TGF-β pathway inhibitor; Inhibits ALK4, ALK5, and ALK7
  • TWS119

    TWS119

    WNT pathway activator; Inhibits GSK3β
  • SAG

    SAG

    Hedgehog pathway activator; Activates Smoothened (SMO)

Buffers and Solutions (42)

Training and Education (41)

  • PSC Training Course

    Pluripotent Stem Cell Training

    Training to support the culture of hPSCs and their differentiation towards cerebral organoids, intestinal organoids, cardiomyocytes, or hematopoietic progenitors

Uncategorized (41)

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