Traditionally, rodents have been popular model organisms for neurological disease research, owing to the difficulty of obtaining human brain tissue for experimental studies. However, because of differences in brain development and signaling pathways, these animal models may not be fully representative of human disease pathology. In recent years, driven by technological advances, researchers have begun using induced pluripotent stem (iPS) cells to generate more representative models for studying human neurological disease. These iPS cell-based models hold tremendous potential for the study of human neurological disease. Researchers can now generate patient-specific differentiated cell types, bridging the gap between studies using animal models, and clinical research.