· Promotes reprogramming of human somatic cells to induced pluripotent stem (iPS) cells using only a single factor, OCT4 (Zhu et al.).
MAINTENANCE AND SELF-RENEWAL
· Supports self-renewal of mouse and human embryonic stem (ES) cells, in the absence of exogenously added growth factors (Ware et al.).
· Promotes differentiation to hepatocytes from mouse and human ES cells (Hay et al.; Zhou et al.).
· Promotes differentiation to definitive endoderm and islet-like cells from human ES cells (Jiang et al.).
· Enhances osteogenic and suppresses adipogenic differentiation from human mesenchymal cells (Chen et al.; Lee et al.).
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