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Human Recombinant FGF-8A

Fibroblast growth factor 8A

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From: 151 USD

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Fibroblast growth factor 8A
From: 151 USD

Overview

Fibroblast growth factor 8A (FGF-8A) is a member of the fibroblast growth factor (FGF) family and is an isoform of FGF-8. FGF-8A binds the FGF receptor (FGFR) and activates Ras/MAPK signaling (Hulstrand & Houston). The FGF family possesses broad mitogenic and cell survival activities (Folkman & Klagsbrun; Kimelman & Kirschner) and is involved in a variety of biological processes, including cell proliferation, differentiation, survival, and apoptosis (Folkman & Klagsbrun; Klagsbrun; Rifkin & Moscatelli). FGF-8 RNA is spliced to produce 4 protein isoforms in humans: FGF-8A, FGF-8B, FGF-8E, and FGF-8F. The functional differences are not fully understood; however, studies in zebrafish and Xenopus show that FGF-8A is required for endoderm morphogenesis and neurogenesis (Choe & Crump; Hulstrand & Houston).
Alternative Names:
AIGF, AIGFKAL6, Androgen-induced growth factor, FGF8, FGF-8, Fibroblast growth factor 8 (androgen-induced), Fibroblast growth factor 8, HBGF-8, Heparin-binding growth factor 8, MGC149376
Cell Type:
Endoderm, PSC-Derived; Neural Cells, PSC-Derived; Neural Stem and Progenitor Cells; Neurons
Area of Interest:
Epithelial Cell Biology; Neuroscience; Stem Cell Biology
Molecular Weight:
21.3 kDa
Purity:
≥ 95%

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This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant FGF-8A was tested by its ability to promote the proliferation of 3T3 cells in the presence 1 μg/ml of heparin. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 500 ng/mL. (B) 2 μg of Human Recombinant FGF-8A was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.