Human Recombinant FGF-8A

Fibroblast growth factor 8A
Catalog #
78128_C
Fibroblast growth factor 8A
From: 169 USD

Overview

Fibroblast growth factor 8A (FGF-8A) is a member of the fibroblast growth factor (FGF) family and is an isoform of FGF-8. FGF-8A binds the FGF receptor (FGFR) and activates Ras/MAPK signaling (Hulstrand & Houston). The FGF family possesses broad mitogenic and cell survival activities (Folkman & Klagsbrun; Kimelman & Kirschner) and is involved in a variety of biological processes, including cell proliferation, differentiation, survival, and apoptosis (Folkman & Klagsbrun; Klagsbrun; Rifkin & Moscatelli). FGF-8 RNA is spliced to produce 4 protein isoforms in humans: FGF-8A, FGF-8B, FGF-8E, and FGF-8F. The functional differences are not fully understood; however, studies in zebrafish and Xenopus show that FGF-8A is required for endoderm morphogenesis and neurogenesis (Choe & Crump; Hulstrand & Houston).
Subtype
Cytokines, Growth Factors
Alternative Names
AIGF, AIGFKAL6, Androgen-induced growth factor, FGF8, FGF-8, Fibroblast growth factor 8 (androgen-induced), Fibroblast growth factor 8, HBGF-8, Heparin-binding growth factor 8, MGC149376
Cell Type
Endoderm, PSC-Derived, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Neurons
Area of Interest
Epithelial Cell Biology, Neuroscience, Stem Cell Biology
Molecular Weight
21.3 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant FGF-8A
Catalog #
78128, 78128.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant FGF-8A
Catalog #
78128, 78128.1
Lot #
All
Language
English

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Product Applications

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Data and Publications

Data

(A) The biological activity of Human Recombinant FGF-8A was tested by its ability to promote the proliferation of 3T3 cells in the presence 1 μg/ml of heparin. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 500 ng/mL. (B) 2 μg of Human Recombinant FGF-8A was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

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