Human Recombinant FGF-9

Fibroblast growth factor 9

Human Recombinant FGF-9

Fibroblast growth factor 9

From: 492 USD
Catalog #
78161_C
Fibroblast growth factor 9

Overview

Fibroblast growth factor (FGF) 9 is a pleiotropic member of the FGF family. FGFs are heparin-dependent regulators of cell proliferation and differentiation (Itoh & Ornitz). FGF-9 signals by binding FGFR3 (IIIb) and the IIIc splice variants of the FGFR1, FGFR2, and FGFR3 receptors (Santos-Ocampo et al.; Mohammadi et al.; Plotnikov et al.). In mice, deletion of FGF-9 is lethal and expression of FGF-9 affects development of the skeleton, cerebellum, lungs, heart, vascular system, digestive tract, and testes (Colvin et al.; Harada et al.; Lin et al.). Altered levels of FGF-9 have also been reported in various types of human cancers (Leushacke et al.; Abdel-Rahman et al.).
Subtype
Cytokines, Growth Factors
Alternative Names
Fibroblast growth factor-9, GAF, Glia-activating factor, HBGF-9
Cell Type
Airway Cells, Mesenchymal Cells, PSC-Derived, Mesenchymal Stem and Progenitor Cells
Species
Human
Area of Interest
Neuroscience, Organoids, Respiratory Research, Stem Cell Biology
Molecular Weight
23.4 kDa
Purity
≥ 95%

Data Figures

(A) The biological activity of Human Recombinant FGF-9 was tested by its ability to promote the proliferation of 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 2 ng/mL. (B) 2 μg of Human Recombinant FGF-9 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-9 has a predicted molecular mass of 23.4 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78161.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78161.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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