Human Recombinant TGF-beta 1
Overview
TGF-β1 has been used for:
hPSC CULTURE MAINTENANCE
● Use TGF-β1 together with basic fibroblast growth factor (bFGF) to support the culture of undifferentiated human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells (Amit et al. Biol Reprod, 2004).
EXOGENOUS CELL SIGNALING
● Regulate a variety of functions, including cell proliferation, differentiation, and metabolism (Massagué Nat Rev Mol Cell Biol, 2000; McDowell et al. Curr Biol, 1997).
IMMUNE CELL HOMEOSTASIS
● Modulate B cell responses and mediate immunosuppressive effects on T cells and neutrophils (Letterio & Roberts Annu Rev Immunol, 1998).
Related Products
Scientific Resources
Product Documentation
| Document Type | Product Name | Catalog # | Lot # | Language |
|---|---|---|---|---|
|
Document Type
Product Information Sheet
|
Product Name
Human Recombinant TGF-beta 1
|
Catalog #
78067, 78067.1, 78067.2 |
Lot #
All |
Language
English |
|
Document Type
Safety Data Sheet
|
Product Name
Human Recombinant TGF-beta 1
|
Catalog #
78067, 78067.1, 78067.2 |
Lot #
All |
Language
English |
Educational Materials (8)
Product Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Data and Publications
Data
Figure 1. Human Recombinant TGF-beta 1 Is Bioactive
The biological activity of Human Recombinant TGF-beta 1 was tested by the ability to inhibit IL-4-induced HT-2 cell proliferation. Cell proliferation was measured after 2 days of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.17 ng/mL.
Figure 2. Human Recombinant TGF-beta 1 Has High Purity
1 μg of Human Recombinant TGF-beta 1 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
