Genistein
NF-kB, AMPK, and tyrosine kinase pathway inhibitor; Inhibits tyrosine kinase and topoisomerase II and activates PPARγ
Overview
Genistein is a phytoestrogen that exhibits a wide range of biological effects. It acts by competing for the ATP-binding site of tyrosine kinases but does not inhibit the activity of serine- and threonine-specific kinases such as cAMP-dependent protein kinase, protein kinase C, and phosphorylase kinase (Akiyama et al.). Genistein binds to and activates peroxisome proliferator-activated receptor-gamma (PPARγ) and estrogen receptors, leading to a decrease in osteogenesis and an increase in adipogenesis (Dang et al.). Genistein also binds and activates the seven-transmembrane estrogen receptor GPR30 to activate alternative estrogen signaling pathways (Thomas & Dong).
DIFFERENTIATION
· Inhibits adipocyte differentiation in 3T3-L1 cell culture (Hwang et al.).
· Control of osteoblast and adipocyte cell fates in mouse bone marrow cells (Dang et al.).
CANCER RESEARCH
· Inhibits growth of leukemia, lymphoma, neuroblastoma, gastric, breast, and prostate cancer cells (Sarkar & Li).
DIFFERENTIATION
· Inhibits adipocyte differentiation in 3T3-L1 cell culture (Hwang et al.).
· Control of osteoblast and adipocyte cell fates in mouse bone marrow cells (Dang et al.).
CANCER RESEARCH
· Inhibits growth of leukemia, lymphoma, neuroblastoma, gastric, breast, and prostate cancer cells (Sarkar & Li).
Alternative Names
Not applicable
Cell Type
Adipocytes, Cancer Cells and Cell Lines, Mammary Cells, Prostate Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Differentiation
Area of Interest
Cancer, Neuroscience, Stem Cell Biology
CAS Number
446-72-0
Chemical Formula
C₁₅H₁₀O₅
"Molecular Weight
270.2 g/mol
Purity
≥ 98%
Pathway
NF-κB, Tyrosine Kinase, AMPK
Target
PPARγ
Related Products
Related Products
Scientific Resources
Product Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Genistein
Catalog #
72002, 72004 Lot #
All Language
English Educational Materials (4)
Product Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for
Mammary Epithelial Cell Research
Workflow Stages for
Mesenchymal Stem and Progenitor Cell Research
Workflow Stages for
Neural Stem and Progenitor Cell Research
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Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
