Genistein
NF-kB, AMPK, and tyrosine kinase pathway inhibitor; Inhibits tyrosine kinase and topoisomerase II and activates PPARγ
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Genistein -
Genistein -
Label for Genistein -
Label for Genistein
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Overview
Genistein is a phytoestrogen that exhibits a wide range of biological effects. It acts by competing for the ATP-binding site of tyrosine kinases but does not inhibit the activity of serine- and threonine-specific kinases such as cAMP-dependent protein kinase, protein kinase C, and phosphorylase kinase (Akiyama et al.). Genistein binds to and activates peroxisome proliferator-activated receptor-gamma (PPARγ) and estrogen receptors, leading to a decrease in osteogenesis and an increase in adipogenesis (Dang et al.). Genistein also binds and activates the seven-transmembrane estrogen receptor GPR30 to activate alternative estrogen signaling pathways (Thomas & Dong).
DIFFERENTIATION
· Inhibits adipocyte differentiation in 3T3-L1 cell culture (Hwang et al.).
· Control of osteoblast and adipocyte cell fates in mouse bone marrow cells (Dang et al.).
CANCER RESEARCH
· Inhibits growth of leukemia, lymphoma, neuroblastoma, gastric, breast, and prostate cancer cells (Sarkar & Li).
DIFFERENTIATION
· Inhibits adipocyte differentiation in 3T3-L1 cell culture (Hwang et al.).
· Control of osteoblast and adipocyte cell fates in mouse bone marrow cells (Dang et al.).
CANCER RESEARCH
· Inhibits growth of leukemia, lymphoma, neuroblastoma, gastric, breast, and prostate cancer cells (Sarkar & Li).
Alternative Names:
Not applicable
CAS Number:
446-72-0
Chemical Formula:
C₁₅H₁₀O₅
"Molecular Weight:
270.2 g/mol
Purity:
≥ 98%
Pathway:
NF-κB; Tyrosine Kinase; AMPK
Target:
PPARγ
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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.