Tamoxifen

Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor

Tamoxifen

Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor

From: 279 USD
Catalog #
72662_C
Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor

Overview

Tamoxifen is a selective estrogen receptor modulator (SERM), with tissue-specific antagonistic or agonistic effects. Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription. Tamoxifen is commonly used to activate Cre-ER in transgenic conditional models.

CELL LINE DEVELOPMENT
· Used in transgenic models to induce Cre-mediated recombination in conjunction with Cre-ER, a fusion protein consisting of Cre recombinase and a mutant form of the estrogen receptor hormone-binding domain that specifically binds tamoxifen but not estrogen (Feil et al.; Zhang et al.).

CANCER RESEARCH
· Inhibits growth in the human breast cancer cell line, MCF-7 (Katzenellenbogen et al.).
· Antagonist of estrogen receptor action in breast tissue and breast cancer cells (Abe et al.; Horwitz et al.).
Alternative Names
trans-Tamoxifen
Cell Type
Cancer Cells and Cell Lines, Mammary Cells, Pluripotent Stem Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Area of Interest
Cancer, Cell Line Development, Epithelial Cell Biology, Stem Cell Biology
CAS Number
10540-29-1
Chemical Formula
C₂₆H₂₉NO
Molecular Weight
371.5 g/mol
Purity
≥ 95%
Pathway
Estrogen
Target
ER

Scientific Resources

Product Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
Tamoxifen
Catalog #
72662, 72664, 72666
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Tamoxifen
Catalog #
72662
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Tamoxifen
Catalog #
72664, 72666
Lot #
All
Language
English

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Contact STEMCELL Technologies

Our Customer Service, Sales, and Product and Scientific Support departments in North America are available between 6 am and 5 pm Pacific Time (9 am and 8 pm Eastern Time). One of our representatives will be happy to help you by telephone or email. Please complete the form to contact us by email. A representative will get back to you shortly.
  •  

StemCell Technologies Inc. and affiliates ("STEMCELL Technologies") does not share your email address with third parties. StemCell Technologies Inc. will use your email address to confirm your identity and send you newsletters, transaction-related emails, promotional and customer service emails in accordance with our privacy policy. You can change your email preferences at any time.