IDE1

Activin/BMP/TGF-β pathway activator
Catalog #
72512_C
Activin/BMP/TGF-β pathway activator
From: 120 USD

Overview

Inducer of definitive endoderm 1 (IDE1) induces differentiation of mouse or human pluripotent stem cells (PSCs) by activating SMAD2 phosphorylation and NODAL expression (Borowiak et al.). At EC₅₀ = 125 nM, SOX17 expression was induced in mouse ES cells.

DIFFERENTIATION
· Induces differentiation of mouse or human ES cells to definitive endoderm in the absence of Activin A, NODAL, or feeder cells (Borowiak et al.).
Alternative Names
Not applicable
Cell Type
Endoderm, PSC-Derived, Pluripotent Stem Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Differentiation
Area of Interest
Epithelial Cell Biology, Stem Cell Biology
CAS Number
1160927-48-9
Chemical Formula
C₁₅H₁₈N₂O₅
Molecular Weight
306.3 g/mol
Purity
≥ 95%
Pathway
Activin/Nodal/TGFβ

Related Products

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
IDE1
Catalog #
72512, 72514
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
IDE1
Catalog #
72512, 72514
Lot #
All
Language
English

Educational Materials(3)

Brochure
Small Molecules for Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Mini Review
Small Molecules

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Publications (1)

Cell stem cell 2009 APR Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Borowiak M et al.

Abstract

An essential step for therapeutic and research applications of stem cells is the ability to differentiate them into specific cell types. Endodermal cell derivatives, including lung, liver, and pancreas, are of interest for regenerative medicine, but efforts to produce these cells have been met with only modest success. In a screen of 4000 compounds, two cell-permeable small molecules were indentified that direct differentiation of ESCs into the endodermal lineage. These compounds induce nearly 80% of ESCs to form definitive endoderm, a higher efficiency than that achieved by Activin A or Nodal, commonly used protein inducers of endoderm. The chemically induced endoderm expresses multiple endodermal markers, can participate in normal development when injected into developing embryos, and can form pancreatic progenitors. The application of small molecules to differentiate mouse and human ESCs into endoderm represents a step toward achieving a reproducible and efficient production of desired ESC derivatives.
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