Human Recombinant VEGF-165, ACF

Vascular endothelial growth factor, animal component-free

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Vascular endothelial growth factor, animal component-free
From: 210 USD

Overview

Vascular endothelial growth factor (VEGF-165) is a heparin-binding homodimeric glycoprotein involved in embryonic vasculogenesis and angiogenesis. VEGF binds to VEGFR-1 (R1) and VEGFR-2 (R2), and activates Raf/MEK/ERK and PI3K/AKT pathways (Ferrara et al.). It plays an important role in neurogenesis both in vitro and in vivo (Storkebaum et al.). It has neurotrophic effects on neurons of the central nervous system and promotes growth and survival of dopaminergic neurons and astrocytes. VEGF also promotes growth and survival of vascular endothelial cells, monocyte chemotaxis, and colony formation by granulocyte-macrophage progenitor cells (Ferrara et al.). VEGF-165 contains two polypeptide chains of 165 amino acids each. This product is animal component-free.
Alternative Names:
MGC70609, MVCD-1, Vascular endothelial growth factor 2, Vascular endothelial growth factor A, Vascular permeability factor, VEGF­A, VPF
Cell Type:
Angiogenic Cells; Endothelial Cells; Hematopoietic Stem and Progenitor Cells; Mesenchymal Stem and Progenitor Cells; Mesoderm, PSC-Derived; Neural Stem and Progenitor Cells; Pluripotent Stem Cells
Area of Interest:
Angiogenic Cell Research; Endothelial Cell Biology; Neuroscience; Stem Cell Biology
Molecular Weight:
19.3 kDa monomer; 38.6 kDa dimer
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Human Recombinant VEGF-165, ACF was tested by the ability to promote the proliferation of HUVECs. Cell proliferation was measured after 88 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 3.35 ng/mL. (B) Human Recombinant VEGF-165, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.