Human Recombinant TGF-beta 1

Transforming growth factor beta 1
Catalog #
78067_C
Transforming growth factor beta 1
From: 222 USD

Overview

Transforming growth factor beta 1 (TGF-β1) is a member of the TGF-β superfamily and regulates diverse cellular phenotypes. TGF-β1 binds to serine-threonine kinase type I and II receptors and activates signal transduction through SMAD2/3 proteins, thus regulating a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, and metabolism (Massagué; McDowell et al.). During human embryogenesis, TGF-β1 is expressed by endothelial and hematopoietic tissues and acts as an endogenous autocrine growth regulator in those cells (Gatherer et al.). Together with basic fibroblast growth factor (bFGF), TGF-β1 supports the culture of undifferentiated human embryonic stem cells and induced pluripotent stem cells (Amit et al.). TGF-β1 is produced in latent form by many blood cells and is present in high amounts in platelets and bones. Once activated, TGF-β1 helps to maintain immune homeostasis by modulating B cell response and mediating immunosuppressive effects on T cells and neutrophils (Letterio & Roberts).
Subtype
Cytokines, Growth Factors
Alternative Names
Cartilage-inducing factor, Differentiation inhibiting factor, Latency-associated peptide, TGFB1, TGF-beta-1, LAP, Transforming growth factor β 1
Cell Type
B Cells, Mesenchymal Stem and Progenitor Cells, Monocytes, Myeloid Cells, Neural Stem and Progenitor Cells, Pluripotent Stem Cells, T Cells, Regulatory
Species
Human
Area of Interest
Immunology, Neuroscience, Stem Cell Biology
Molecular Weight
12.8 kDa monomer, 25.6 kDa dimer
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant TGF-beta 1
Catalog #
78067, 78067.1, 78067.2
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant TGF-beta 1
Catalog #
78067, 78067.1, 78067.2
Lot #
All
Language
English

Educational Materials (8)

Brochure
Products for Human Pluripotent Stem Cells
Brochure
Tools For Your Immunology Research
Brochure
Cytokines, Chemokines and Growth Factors
Brochure
hPSC-Derived Neural Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Wallchart
Stem Cell States: Naive to Primed Pluripotency
Wallchart
Human Immune Cytokines
Wallchart
Directed Differentiation of Pluripotent Stem Cells

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant TGF-beta 1 was tested by the ability to inhibit IL-4-induced HT-2 cell proliferation. Cell proliferation was measured after 2 days of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.17 ng/mL. (B) 1 μg of Human Recombinant TGF-beta 1 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Contact STEMCELL Technologies

Our Customer Service, Sales, and Product and Scientific Support departments in North America are available between 6 am and 5 pm Pacific Time (9 am and 8 pm Eastern Time). One of our representatives will be happy to help you by telephone or email. Please complete the form to contact us by email. A representative will get back to you shortly.
  •  

StemCell Technologies Inc. and affiliates ("STEMCELL Technologies") does not share your email address with third parties. StemCell Technologies Inc. will use your email address to confirm your identity and send you newsletters, transaction-related emails, promotional and customer service emails in accordance with our privacy policy. You can change your email preferences at any time.