Human Recombinant RANKL

Receptor activator of nuclear factor kappa-B ligand

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Receptor activator of nuclear factor kappa-B ligand
From: 185 USD

Overview

Receptor activator of nuclear factor kappa-B ligand (RANKL) is a member of the tumor necrosis factor (TNF) superfamily (Anderson et al.). Cytokines in the TNF superfamily are involved in a variety of long-term cellular activities such as differentiation, proliferation, and cell death (MacEwan). RANKL is a type II homotrimeric transmembrane protein expressed in both a membrane-bound and secreted form (Ikeda et al.). RANKL binds to the receptor activator of nuclear factor kappa-B (RANK). Upon binding to its receptor, RANKL activates the AKT signaling pathway (Moon et al.). Osteoprotegerin (OPG) may also bind RANKL, and this binding competes with RANKL-RANK binding (Lacey et al.). RANKL is involved in osteoclastogenesis (Lacey et al.; Yasuda et al.) and T cell activation (Wong et al.).
Alternative Names:
CD254, hRANKL2, ODF, OPGL, OPTB2, Osteoclast differentiation factor, soluble Receptor activator of NF-κB ligand, sOdf, TNF-related activation-induced cytokine, TNFSF11, TNF superfamily member 11, TNLG6B, Tumor necrosis factor superfamily member 11, TRAN
Cell Type:
Airway Cells; Cancer Cells and Cell Lines; Dendritic Cells; Intestinal Cells; Mammary Cells; Osteoblasts; Other; Pancreatic Cells; Prostate Cells; T Cells
Species:
Human
Area of Interest:
Cancer Research; Stem Cell Biology
Molecular Weight:
19.7 kDa
Purity:
≥ 95%

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Data

(A) The biological activity of Human Recombinant RANKL was tested by its ability to induce production of embryonic alkaline phosphatase in RAW-Blue™ macrophage reporter cells. Alkaline phosphatase production was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which alkaline phosphatase activity is at 50% of maximum. The EC50 in the above example is 38.8 ng/mL. (B) Human Recombinant RANKL was resolved with SDS-PAGE under reducing (+) conditions and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant RANKL has a predicted molecular mass of 19.7 kDa.

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