Human Recombinant IL-7

Interleukin 7

Human Recombinant IL-7

Interleukin 7

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Interleukin 7
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Overview

Interleukin 7 (IL-7) is a member of the Type I cytokine family that is critical for T and B cell development and survival. It is produced by non-hematopoietic cells in the thymus, lymphoid organs, and by bone marrow stromal cells (Lundström et al.). IL-7 binds to a receptor (IL-7R) composed of common gamma chain and IL-7Ra (CD127) and signals through the JAK/STAT and PI3K pathways. IL-7 regulates the survival of naïve and memory CD4+ and CD8+ T cells, γδ T cells, NK T cells, innate lymphoid cells, and T regulatory cells (Carrette & Surh). Although a deficiency in IL-7R still permits the generation of normal numbers of peripheral B cells in humans, stimulation of human B cell precursors with IL-7 could promote STAT-5-dependent proliferation and survival in vitro (Clark et al.; Corfe & Paige).
Subtype
Cytokines
Cell Type
Hematopoietic Stem and Progenitor Cells, Lymphocytes
Species
Human
Area of Interest
Immunology, Stem Cell Biology
Purity
≥ 95%

Data Figures

(A) The biological activity of Human Recombinant IL-7 was tested by its ability to promote the proliferation of 2E8 cells. Cell proliferation was measured after 66 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.06 - 0.09 ng/mL.
(B) 1 μg of Human Recombinant IL-7 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-7 has a predicted molecular mass of 17.5 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78053.3, 78053.1, 78053
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78053.3, 78053.1, 78053
Lot #
All
Language
English

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