Airway Epithelial Cell Research

The large airway epithelium is composed of three major cell types: basal cells that line the basement membrane, goblet cells that produce and secrete mucus, and ciliated cells that drive mucociliary clearance of inhaled particulates through the coordinated action of their apical cilia. See MoreModel the airway epithelium using air-liquid interface (ALI) cultures to generate a pseudostratified mucociliated epithelium with these major cell types. Extensive differentiation of the cells results in a physiologically relevant epithelial layer that can be used to study respiratory biology, disease and drug interactions. For high-throughput studies, culture airway cells in an insert-free sphere culture system to drive mucociliary differentiation on a larger scale.