Anti-Human ACE2 Antibody, Clone AC384

Mouse monoclonal IgG1 antibody against human angiotensin-converting enzyme 2 (ACE2)

Anti-Human ACE2 Antibody, Clone AC384

Mouse monoclonal IgG1 antibody against human angiotensin-converting enzyme 2 (ACE2)

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Mouse monoclonal IgG1 antibody against human angiotensin-converting enzyme 2 (ACE2)
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Overview

The AC384 antibody reacts with angiotensin-converting enzyme 2 (ACE2), a type I integral membrane protein, which includes a short C-terminal cytoplasmic domain made of 22 amino acids, a transmembrane domain, and a large N-terminal ectodomain made of 740 amino acids. The N-terminal domain of ACE2 contains a catalytic zinc-binding motif, which shares a 42% similarity to the catalytic binding domain of ACE. Despite the similarity in catalytic domains, ACE2 functions as a carboxypeptidase, while ACE functions as either a peptidyl dipeptidase or an endopeptidase. In humans, ACE2 is a key regulator of the renin-angiotensin system, where it catalyzes the cleavage of the vasoconstrictor peptide angiotensin II to angiotensin 1-7. Expression of ACE2 can be found on endothelial cells throughout the body, such as in the kidney, heart, and lungs. In the airways leading to the lungs, ACE2 provides the main entry point for SARS-CoV-2 (2019-nCoV). Once the SARS-CoV-2 Spike Protein binds to ACE2, viral fusion with the host cell membrane can occur, resulting in viral RNA genome delivery.
Target Antigen
Angiotensin-Converting Enzyme 2
Alternative Names
SARS Receptor, Angiotensin-converting Enzyme 2, ACEH, Metalloprotease MPROT15, SARS-CoV-2 Receptor
Reactive Species
Human
Conjugation
Biotin, Unconjugated
Host Species
Mouse
Cell Type
Airway Cells, Epithelial Cells
Application
ELISA, Flow Cytometry, Neutralization and Blocking, Western Blotting
Area of Interest
Disease Modeling, Epithelial Cell Biology, Respiratory Research
Clone
AC384
Gene ID
59272
Isotype
IgG1, kappa

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-0761
Lot #
All
Language
English
Catalog #
100-0760, 100-0759
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-0761
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-0760, 100-0759
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.