Mouse Recombinant TRAIL

TNF-related apoptosis-inducing ligand
Catalog #
78122_C
TNF-related apoptosis-inducing ligand
From: 185 USD

Overview

TRAIL (TNF-related apoptosis-inducing ligand) belongs to the tumor necrosis factor (TNF) superfamily and is associated with initiating apoptosis. TRAIL has four major receptors: two death receptors DR4 and DR5, and two decoy receptors DcR1 and DcR2. TRAIL binds to the death receptors, which recruits the Fas-associated death domain (FADD) and activates caspases 8 and 10, which eventually leads to apoptosis (Pitti et al.; Wiley et al.; Zauli & Secchiero). It has been shown that mice lacking the expression of TRAIL have defects in thymocyte apoptosis and negative selection, and these mice had increased susceptibility to autoimmune diseases (Lamhamedi-Cherradi et al.).
Subtype
Cytokines
Alternative Names
TL2, TNF-related apoptosis-inducing ligand, TNFSF10
Cell Type
T Cells
Species
Mouse
Area of Interest
Immunology
Molecular Weight
20 kDa
Purity
≥ 98%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Mouse Recombinant TRAIL
Catalog #
78122.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Mouse Recombinant TRAIL
Catalog #
78122.1
Lot #
All
Language
English

Educational Materials (1)

Wallchart
Human Immune Cytokines

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Mouse Recombinant TRAIL was tested by its ability to inhibit the proliferation of RPMI-8226 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 100 ng/mL. (B) 2 μg of Mouse Recombinant TRAIL was resolved with SDS-PAGE under reducing (+) conditions and visualized by Coomassie Blue staining.

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