Human Recombinant PDGF-AB

Platelet-derived growth factor AB
Catalog #
78096_C
Platelet-derived growth factor AB
From: 185 USD

Overview

Platelet-derived growth factor (PDGF) is a dimeric glycoprotein consisting of two disulfide bridge-stabilized polypeptide chains, A and B, which are assembled as heterodimers (PDGF-AB) or homodimers (PDGF-AA and PDGF-BB) (Fretto et al.; Westermark & Heldin). PDGF signals through the receptor tyrosine kinases PDGFRalpha and PDGFRbeta. It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src, and PI3K/AKT (Kim et al.). PDGF is a potent mitogen for cells of mesenchymal origin- like fibroblasts, glial cells, and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues (Fretto et al.; Sachinidis et al.). It has been shown that PDGF-AB together with 5-Azacytidine (Catalog #72012), induces the conversion of mature bone and fat cells into tissue-regenerative multipotent stem cells (Chandrakanthan et al.).
Subtype
Cytokines, Growth Factors
Alternative Names
GDGF, Glioma-derived growth factor, ODGF, Osteosarcoma-derived growth factor, Platelet-derived growth factor-AB
Cell Type
Mesenchymal Cells, PSC-Derived, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Neurons, Osteoblasts, Other
Species
Human
Area of Interest
Neuroscience, Stem Cell Biology
Molecular Weight
14.4 kDa alpha monomer, 12.4 kDa beta monomer; 26.8 kDa dimer
Purity
≥ 95%

Related Products

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant PDGF-AB
Catalog #
78096, 78096.1, 78096.2
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant PDGF-AB
Catalog #
78096, 78096.1, 78096.2
Lot #
All
Language
English

Educational Materials(1)

Brochure
Cytokines, Chemokines and Growth Factors

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant PDGF-AB was tested by its ability to promote the proliferation of BALB/c 3T3 cells. Cell proliferation was measured after 46 hours using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 1.8 ng/mL. (B) 1 μg of Human Recombinant PDGF-AB was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant PDGF-AB is a heterodimer of one 14.4 kDa alpha-chain and 12.4 kDa beta-chain with a predicted total molecular mass of 26.8 kDa.

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