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Interferon-gamma (IFN-γ), also known as type II interferon, is produced by T and NK cells, and in smaller amounts by dendritic cells and macrophages. IFN-γ is controlled by cytokines such as IL-12 and IL-18 secreted in response to infection (Schroder et al.). IFN-γ binds to a receptor complex and initiates signal transduction via the JAK/STAT pathway; this culminates in the transcription and activation of many genes that control a diverse array of immunological functions (de Weerd and Nguyen; Krause et al.). IFN-γ stimulates the antimicrobial and anti-tumor activity of macrophages, NK cells, and neutrophils (Billiau & Matthys) by promoting the activation of microbial effector functions such as production of reactive oxygen species, NO intermediates, and complement (Schroder et al.). IFN-γ enhances MHC class I and II expression in dendritic cells and mononuclear phagocytes, as well as the production of IL-12 by dendritic cells. In B cells, IFN-γ stimulates survival and growth in both mouse and human cells, and redirects B cells from proliferation towards differentiation. IFN-γ favors the development of Th1 vs Th2 cells and stimulates monocyte differentiation and function (Schroder et al.). This product is animal component-free.
Interferon gamma, Type II interferon
B Cells, Hematopoietic Stem and Progenitor Cells, Intestinal Cells, Mesenchymal Stem and Progenitor Cells, T Cells
(A) The biological activity of Human Recombinant IFN-gamma, ACF was tested by its ability to induce alkaline phosphatase activity in HEK-Blue™ IFN-gamma-responsive indicator cells. The EC50 is defined as the effective concentration of the ligand at which alkaline phosphatase activity is at 50% of maximum. The EC50 in the above example is 0.153 ng/ml.
(B) 1 μg of Human Recombinant IFN-gamma, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IFN-gamma, ACF has a predicted molecular mass of 16.9 kDa.
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