Mouse Recombinant IFN-gamma

Interferon-gamma

Mouse Recombinant IFN-gamma

Interferon-gamma

From: 81 USD
Catalog #
78021_C
Interferon-gamma

Overview

Interferon-gamma (IFN-γ), also known as type II interferon, is produced by T and NK cells, and in smaller amounts by dendritic cells and macrophages. IFN-γ is controlled by cytokines such as IL-12 and IL-18 secreted in response to infection (Schroder et al.). IFN-γ binds to a receptor complex and initiates signal transduction via the JAK/STAT pathway; this culminates in the transcription and activation of many genes that control a diverse array of immunological functions (De Weerd and Nguyen; Krause et al.). IFN-γ stimulates the antimicrobial and anti-tumor activity of macrophages, NK cells, and neutrophils (Billiau & Matthys) by promoting the activation of microbial effector functions such as production of reactive oxygen species, NO intermediates, complement, etc. (Schroder et al.). IFN-γ enhances MHC class I and II expression in dendritic cells and mononuclear phagocytes, as well as the production of IL-12 by dendritic cells. In B cells, IFN-γ stimulates survival and growth in both mouse and human cells, and redirects B cells from proliferation towards differentiation. IFN-γ favors the development of Th1 vs Th2 cells and stimulates monocyte differentiation and function (Schroder et al.).
Subtype
Cytokines
Alternative Names
Interferon gamma, Type II interferon
Cell Type
B Cells, Hematopoietic Stem and Progenitor Cells, Intestinal Cells, Mesenchymal Stem and Progenitor Cells, T Cells
Species
Mouse
Area of Interest
Epithelial Cell Biology, Immunology, Stem Cell Biology
Molecular Weight
15.7 kDa
Purity
≥ 95%

Data Figures

(A) The biological activity of Mouse Recombinant IFN-gamma was measured with L929 cells exposed to the encephalomyocarditis (EMC) virus in a cytopathic effect (CPE) assay. The specific activity in the above example is 1.25 x 10^6 units/mg.
(B) 1 μg of Mouse Recombinant IFN-gamma was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IFN-gamma has a predicted molecular mass of 15.7 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78021, 78021.1, 78021.2
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78021, 78021.1, 78021.2
Lot #
All
Language
English

Resources and Publications

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