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Human Recombinant IL-12

Interleukin 12

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Human Recombinant IL-12

Interleukin 12

From: 171 USD
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Interleukin 12
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Overview

Interleukin 12 (IL-12p70) is a heterodimeric cytokine composed of p35 and p40 subunits. IL-12 is produced by monocytes, macrophages, dendritic cells, neutrophils, and B cells in response to bacterial products and cytokines such as IFN-γ. The IL-12 receptor is expressed on T, NK, and dendritic cells. Upon binding, IL-12 initiates signaling via the JAK/STAT signaling pathway and stimulates NK, B, and T cells to produce IFN-γ (Watford et al.). It also regulates cytokine synthesis, proliferation of T and NK cells, and stimulates differentiation of CD4+ and CD8+ T cells (Germann & Rüde). Mice that are deficient in IL-12 are susceptible to many intracellular pathogens and have impaired IFN-γ secretion, Th1 differentiation, and NK cytolytic activity; however, Th2 development and IL-4 production are enhanced (Watford et al.).
Subtype
Cytokines
Cell Type
B Cells, Hematopoietic Stem and Progenitor Cells, Lymphocytes, NK Cells, T Cells
Species
Human
Area of Interest
Immunology, Stem Cell Biology
Purity
≥ 95%

Data Figures

(A) The biological activity of Human Recombinant IL-12 was tested by its ability to produce IFN-gamma in NK cells co-stimulated with IL18. The EC50 is defined as the effective concentration of the growth factor at which IFN-gamma production is at 50% of maximum. The EC50 in the above example is less than 2 ng/mL.
(B) 2 μg of Human Recombinant IL-12 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-12 has a predicted molecular mass of 22.5 - 34.7 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant IL-12
Catalog #
78027.2
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Human Recombinant IL-13
Catalog #
78027
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Human Recombinant IL-14
Catalog #
78027.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-12
Catalog #
78027.2
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-13
Catalog #
78027
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-14
Catalog #
78027.1
Lot #
All
Language
English

Applications

Resources and Publications

Educational Materials (3)

Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors
Tools for Your Immunology Research
Brochure
Tools for Your Immunology Research
Human Immune Cytokines
Wallchart
Human Immune Cytokines

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Quality Statement:

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.

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