Anti-Beta-Tubulin III Antibody, Clone TUJ1

Mouse monoclonal IgG2a antibody against human, mouse, rat beta­tubulin III

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Anti-Beta-Tubulin III Antibody, Clone TUJ1

Mouse monoclonal IgG2a antibody against human, mouse, rat beta-tubulin III, unconjugated

250 µL
Catalog #60052
686 USD

Overview

The TUJ1 antibody reacts with beta-tubulin III, an ~50 - 55 kDa structural protein that is a component of tubulin. Tubulin is the major component of microtubules within the cytoskeleton and is assembled from heterodimers of alpha and beta tubulin subunits. The beta III isoform of tubulin, also known as neuron-specific class III beta-tubulin, is expressed primarily in neurons and is widely used as a marker to distinguish neurons from other cell types. Beta-tubulin III contributes to microtubule formation in neuronal cell bodies and axons, a function involving GTP binding, and plays roles in axonal transport, neuronal cell proliferation, and differentiation. It is highly expressed in several types of cancer and is a predictive and prognostic marker for various tumors, for example, being found in neoplastic but not in normal glial cells. The TUJ1 antibody is expected to recognize all mammalian homologs of beta-tubulin III and the epitope has reportedly been mapped to the C-terminal 15 amino acids of the protein.
Subtype:
Primary Antibodies
Target Antigen:
Beta-Tubulin III
Alternative Names:
CDCBM, CDCBM1, CFEOM3, CFEOM3A, Class III beta-tubulin, FEOM3, TUBB4, Tubulin beta-3 chain, Tubulin beta-III, Tubulin beta-4 chain
Reactive Species:
Human; Mouse; Other; Rat
Conjugation:
Unconjugated
Host Species:
Mouse
Cell Type:
Neural Cells, PSC-Derived; Neurons
Application:
Flow Cytometry; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation; Western Blotting
Area of Interest:
Neuroscience; Stem Cell Biology
Clone:
TUJ1
Gene ID:
10381
Isotype:
IgG2a, kappa

Scientific Resources

Educational Materials

(6)

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

E18 cortical rat neurons were cultured using NeuroCult™ SM1 Neuronal Culture Kit on poly-L-ornithine and laminin-coated glass coverslips, then fixed and labeled with Anti-Beta-Tubulin III Antibody, Clone TUJ1, followed by donkey anti-mouse IgG, Alexa Fluor® 488, and counterstained with DAPI.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.