Human Recombinant VEGF-165, ACF

Vascular endothelial growth factor, animal component-free
Catalog #
78159_C
Vascular endothelial growth factor, animal component-free
From: 204 USD

Overview

Vascular endothelial growth factor (VEGF-165) is a heparin-binding homodimeric glycoprotein involved in embryonic vasculogenesis and angiogenesis. VEGF binds to VEGFR-1 (R1) and VEGFR-2 (R2), and activates Raf/MEK/ERK and PI3K/AKT pathways (Ferrara et al.). It plays an important role in neurogenesis both in vitro and in vivo (Storkebaum et al.). It has neurotrophic effects on neurons of the central nervous system and promotes growth and survival of dopaminergic neurons and astrocytes. VEGF also promotes growth and survival of vascular endothelial cells, monocyte chemotaxis, and colony formation by granulocyte-macrophage progenitor cells (Ferrara et al.). VEGF-165 contains two polypeptide chains of 165 amino acids each. This product is animal component-free.
Subtype
Cytokines, Growth Factors
Alternative Names
MGC70609, MVCD-1, Vascular endothelial growth factor 2, Vascular endothelial growth factor A, Vascular permeability factor, VEGF­A, VPF
Cell Type
Angiogenic Cells, Endothelial Cells, Hematopoietic Stem and Progenitor Cells, Mesenchymal Stem and Progenitor Cells, Mesoderm, PSC-Derived, Neural Stem and Progenitor Cells, Pluripotent Stem Cells
Area of Interest
Angiogenic Cell Research, Endothelial Cell Biology, Neuroscience, Stem Cell Biology
Molecular Weight
19.3 kDa monomer; 38.6 kDa dimer
Purity
≥ 95%

Related Products

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant VEGF-165, ACF
Catalog #
78159, 78159.1, 78159.2
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant VEGF-165, ACF
Catalog #
78159, 78159.1, 78159.2
Lot #
All
Language
English

Educational Materials(6)

Brochure
Cytokines, Chemokines and Growth Factors
Brochure
Small Molecules for Stem Cell Research
Brochure
BrainPhys™ Neuronal Medium for Improved Neuronal Function
Wallchart
Identification of Colonies Derived from Human Hematopoietic Progenitors
Webinar
1:06:52
New Tools for the Ex Vivo Expansion of Human Hematopoietic Stem and Progenitor Cells
Mini Review
Hematopoietic Stem and Progenitor Cells (HSPCs): Isolation, Culture, and Assays

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant VEGF-165, ACF was tested by the ability to promote the proliferation of HUVECs. Cell proliferation was measured after 88 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 3.35 ng/mL. (B) Human Recombinant VEGF-165, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

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