Compound E

Notch pathway inhibitor; Inhibits Notch receptor and amyloid precursor protein
Catalog #
73952_C
Notch pathway inhibitor; Inhibits Notch receptor and amyloid precursor protein
From: 218 USD

Overview

Compound E is a potent, cell-permeable, selective inhibitor that blocks the cleavage of both gamma-secretase and the Notch intracellular domain with similar IC50 values, ranging from 0.24 to 0.37 nM (Beher et al.; Seiffert et al.).


DIFFERENTIATION
· Inhibits growth, differentiation, and motility of neuroblastoma cells (Ferrari-Toninelli et al.).
· Accelerates the differentiation of human embryonic stem cells into primitive neural stem cells (Li et al.).
Alternative Names
γ-secretase inhibitor XXI
Cell Type
Brain Tumor Stem Cells, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Differentiation, Maintenance
Area of Interest
Neuroscience
CAS Number
209986-17-4
Chemical Formula
C₂₇H₂₄F₂NO
"
Molecular Weight
490.5 g/mol
Purity
≥ 98%
Pathway
Notch
Target
γ-Secretase

Related Products

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Compound E
Catalog #
73952, 73954
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Compound E
Catalog #
73952, 73954
Lot #
All
Language
English

Educational Materials(5)

Brochure
Small Molecules for Stem Cell Research
Brochure
Small Molecules for Cancer Research
Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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