LDN193189

BMP pathway inhibitor; Inhibits ALK1, ALK2, ALK3, and ALK6

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BMP pathway inhibitor; Inhibits ALK1, ALK2, ALK3, and ALK6
From: 190 USD

Overview

LDN193189 is a potent inhibitor of the bone morphogenetic (BMP) pathway, inhibiting ALK1, ALK2, ALK3, and ALK6 (IC50 = 0.8, 0.8, 5.3, and 16.7 nM respectively; Sanvitale et al.). It is a derivative of Dorsomorphin (Catalog #72102) that is typically used at approximately 100-fold lower concentrations (Sanvitale et al.; Vogt et al.). This product is supplied as the dihydrochloride salt of the molecule and it is the most soluble version of LDN193189.

DIFFERENTIATION
· Promotes differentiation of neural progenitor cells from human pluripotent stem cells (Chambers et al.; Kriks et al.).
· Promotes differentiation of neural crest cells from human pluripotent stem cells (Kreitzer et al.).
· Promotes differentiation of anterior foregut endoderm from human and mouse pluripotent stem cell-derived definitive endoderm (Kearns et al.).
· Promotes differentiation of sensory epithelial cells of the inner ear from mouse embryonic stem cells (Koehler et al.).

CANCER RESEARCH
· Inhibits prostate and breast cancer tumor growth (Balboni et al.; Lee et al.).
· Prevents ovarian cancer cell proliferation (Tsai et al.).
Alternative Names:
DM-3189
CAS Number:
1435934-00-1
Chemical Formula:
C₂₅H₂₂N₆ · 2HCl
Molecular Weight:
479.4 g/mol
Purity:
> 98%
Pathway:
BMP
Target:
ALK1; ALK2; ALK3; ALK6

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This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.