Genome Editing
The use of genome editing tools to generate specific changes to the DNA sequence of human pluripotent stem cells (hPSCs), by either introducing or correcting mutations, provides more accurate modeling of human disease when the gene-edited hPSCs are subsequently differentiated into human-derived tissues.
Products
Cell Culture Media and Supplements (42)
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New
StemSpan™-ACF Without Phenol Red
cGMP medium, for culture and expansion of human hematopoietic cells -
CloneR™
Defined supplement for single-cell cloning of human ES and iPS cells
Genome Editing and Molecular Tools (49)
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ArciTect™ sgRNA
Custom-designed single guide RNA for CRISPR-Cas9 genome editing -
ArciTect™ Cas9-eGFP Nuclease
Enhanced green fluorescent protein (eGFP)-tagged Cas9 nuclease for the generation of double-strand breaks in CRISPR-Cas9 genome editing -
ArciTect™ Cas9 Nickase
Modified Cas9 nuclease for the generation of single-strand breaks in CRISPR-Cas9 genome editing -
ArciTect™ Cas9 Nuclease
Cas9 nuclease for the generation of double-strand breaks in CRISPR-Cas9 genome editing
Cultureware and General Supplies (42)
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Costar® Microcentrifuge Tubes
Non-sterile, clear, polypropylene snap-cap microcentifuge tubes -
Axygen® Thin-Wall PCR Tubes
Non-sterile, clear, RNase/DNase-free, polypropylene conical tubes with caps
Small Molecules (47)
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KU0060648
NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK) -
Nocodazole
Microtubule polymerization inhibitor; Inhibits beta-tubulin -
NU7441
NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK) -
RS-1
HDR pathway enhancer; Enhances RAD51