RS-1

HDR pathway enhancer; Enhances RAD51

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RS-1

HDR pathway enhancer; Enhances RAD51

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HDR pathway enhancer; Enhances RAD51

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Overview

RS-1 is an enhancer of RAD51, an enzyme that assists in the homology-directed repair (HDR) pathway of DNA double-strand breaks, and is reported to function by stabilizing the active form of RAD51 and by enhancing recombinogenic activity of the enzyme (Jayathilaka et al.). Via this mechanism, RS-1 can stimulate HDR, thereby enhancing precise HDR-dependent CRISPR-Cas9 genome editing in some cell lines (Pinder et al.; Song et al.).

GENOME EDITING
· Promotes HDR, which is reported to enhance knock-in efficiency of CRISPR-Cas9 genome editing (Pinder et al.; Song et al.); however, these effects are cell type-specific and context-dependent (Xie et al.; Zhang et al.).

CANCER RESEARCH
· Stimulates the DNA-binding activity of RAD51 to promote cancer cell death and induce anti-tumor responses in a mouse xenograft tumor model (Mason et al.).

Cancer Cells and Cell Lines

Human, Mouse, Non-Human Primate, Other, Rat

Genome Editing

Cancer

312756-74-4

C₂₀H₁₆Br₂N₂O₃S

≥ 95%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type

Product Name

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Document Type

Product Information Sheet

Product Name

RS-1

Catalog #

74094, 74092

Lot #

All

Language

English

Document Type

Safety Data Sheet

Product Name

RS-1

Catalog #

74094, 74092

Lot #

All

Language

English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area

Workflow Stages

Workflow Stages for Genome Editing

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Resources and Publications

Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.

RS-1

HDR pathway enhancer; Enhances RAD51

RS-1

HDR pathway enhancer; Enhances RAD51

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Overview

Protocols and Documentation

Applications

Resources and Publications

Educational Materials (3)

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