RS-1
HDR pathway enhancer; Enhances RAD51
Overview
RS-1 is an enhancer of RAD51, an enzyme that assists in the homology-directed repair (HDR) pathway of DNA double-strand breaks, and is reported to function by stabilizing the active form of RAD51 and by enhancing recombinogenic activity of the enzyme (Jayathilaka et al.). Via this mechanism, RS-1 can stimulate HDR, thereby enhancing precise HDR-dependent CRISPR-Cas9 genome editing in some cell lines (Pinder et al.; Song et al.).
GENOME EDITING
· Promotes HDR, which is reported to enhance knock-in efficiency of CRISPR-Cas9 genome editing (Pinder et al.; Song et al.); however, these effects are cell type-specific and context-dependent (Xie et al.; Zhang et al.).
CANCER RESEARCH
· Stimulates the DNA-binding activity of RAD51 to promote cancer cell death and induce anti-tumor responses in a mouse xenograft tumor model (Mason et al.).
GENOME EDITING
· Promotes HDR, which is reported to enhance knock-in efficiency of CRISPR-Cas9 genome editing (Pinder et al.; Song et al.); however, these effects are cell type-specific and context-dependent (Xie et al.; Zhang et al.).
CANCER RESEARCH
· Stimulates the DNA-binding activity of RAD51 to promote cancer cell death and induce anti-tumor responses in a mouse xenograft tumor model (Mason et al.).
Alternative Names
Not applicable
Cell Type
Cancer Cells and Cell Lines
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Genome Editing
Area of Interest
Cancer Research
CAS Number
312756-74-4
Chemical Formula
C₂₀H₁₆Br₂N₂O₃S
Molecular Weight
524.2 g/mol
Purity
≥ 95%
Related Products
Related Products
Scientific Resources
Product Documentation
| Document Type | Product Name | Catalog # | Lot # | Language |
|---|---|---|---|---|
|
Document Type
Product Information Sheet
|
Product Name
RS-1
|
Catalog # 74092, 74094 |
Lot # All |
Language English |
|
Document Type
Safety Data Sheet
|
Product Name
RS-1
|
Catalog # 74092, 74094 |
Lot # All |
Language English |
Educational Materials(5)
Brochure
Small Molecules for Stem Cell Research
Brochure
Small Molecules for Cancer Research
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Mini Review
Small Molecules
Product Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for
Genome Editing
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
