KU0060648

NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

KU0060648

NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

From: 291 USD
Catalog #
74062_C
NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

Overview

KU0060648 is an ATP-competitive and highly potent inhibitor of DNA-dependent protein kinase (DNA-PK), with IC₅₀ values of 19 nM in MCF7 human breast cancer cells and 170 nM in SW620 human colon cancer cells. KU0060648 also inhibits phosphoinositide 3-kinase (PI3K) with IC₅₀ values of 39 nM in MCF7 cells and > 10 µM in SW620 cells, which suggests a cell-dependent mechanism (Munck et al.).


GENOME EDITING
· Reduces the frequency of non-homologous end joining (NHEJ) and increases the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Robert et al.).


CANCER RESEARCH
· Inhibits tumor growth and sensitizes human cancer cells to DNA double-strand-break (DSB)-inducing therapies (chemo- or radio-therapy) by inhibiting both DNA-PK and PI3K and preventing the execution of DSB repair (Chen et al.; Dietlein et al.; Munck et al.).
Alternative Names
Not applicable
Cell Type
Cancer Cells and Cell Lines
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Genome Editing
Area of Interest
Cancer
CAS Number
881375-00-4
Chemical Formula
C₃₃H₃₄N₄O₄S
Molecular Weight
582.7 g/mol
Purity
≥ 98%
Pathway
PI3K/AKT

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
KU0060648
Catalog #
74062, 74064
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
KU0060648
Catalog #
74062, 74064
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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