KU0060648
NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)
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Overview
GENOME EDITING
· Reduces the frequency of non-homologous end joining (NHEJ) and increases the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Robert et al.).
CANCER RESEARCH
· Inhibits tumor growth and sensitizes human cancer cells to DNA double-strand-break (DSB)-inducing therapies (chemo- or radio-therapy) by inhibiting both DNA-PK and PI3K and preventing the execution of DSB repair (Chen et al.; Dietlein et al.; Munck et al.).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
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Resources and Publications
Educational Materials (3)
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.