NU7441

NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

NU7441

NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

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NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)
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Overview

NU7441 is an inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme involved in the non-homologous end joining (NHEJ) DNA repair pathway. It is highly selective for DNA-PK, with an IC₅₀ of 14 nM (Leahy et al.).

GENOME EDITING
·Reduces the frequency of NHEJ and increases the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Robert et al.).

CANCER RESEARCH
· Sensitizes human cancer cell lines to DNA double-strand-break-inducing therapies (chemo- or radio-therapy) by inhibiting DNA-PK activity and delaying the repair of double-strand breaks (Ciszewski et al.; Shaheen et al.; Yang et al.; Zhao et al.).
Cell Type
Cancer Cells and Cell Lines, Prostate Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Genome Editing
Area of Interest
Cancer
CAS Number
503468-95-9
Chemical Formula
C₂₅H₁₉NO₃S
Purity
≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
NU7441
Catalog #
74082, 74084
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
NU7441
Catalog #
74082, 74084
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.