Compound E

Notch pathway inhibitor; Inhibits Notch receptor and amyloid precursor protein

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Notch pathway inhibitor; Inhibits Notch receptor and amyloid precursor protein
From: 212 USD

Overview

Compound E is a potent, cell-permeable, selective inhibitor that blocks the cleavage of both gamma-secretase and the Notch intracellular domain with similar IC50 values, ranging from 0.24 to 0.37 nM (Beher et al.; Seiffert et al.).


DIFFERENTIATION
· Inhibits growth, differentiation, and motility of neuroblastoma cells (Ferrari-Toninelli et al.).
· Accelerates the differentiation of human embryonic stem cells into primitive neural stem cells (Li et al.).
Alternative Names:
γ-secretase inhibitor XXI
CAS Number:
209986-17-4
Chemical Formula:
C₂₇H₂₄F₂NO
"
Molecular Weight:
490.5 g/mol
Purity:
≥ 98%
Pathway:
Notch
Target:
γ-Secretase

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This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.