Human Recombinant IL-4

Interleukin 4
Catalog #
78045_C
Interleukin 4
From: 185 USD

Overview

Human Interleukin 4 (IL-4) is important for immune responses to helminth infection as well as in allergic responses (Olpihant et al.). The IL-4 receptor consists of a heterodimer of IL-4Ra and common gamma chain. IL-4 receptor engagement leads to the activation of JAK1/3 and the recruitment of STAT6 and IRS1/2 (Nelms et al.). IL-4 drives immunoglobulin class switching in B cells (to IgE, IgG4), mast cell hyperplasia, mucus production, and the differentiation of naïve T cells into Th2 cells, which produce IL-4, IL-5, IL-10, and IL-13 (Bao et al.; Nelms et al.; Olpihant et al.). In addition to Th2 cells, IL-4 is produced by CD4+ NK T cells, γ/δ T cells, activated basophils, eosinophils, and mast cells. Human IL-4 does not cross-react with mouse cells (Park et al.).
Subtype
Cytokines
Alternative Names
B cell stimulating factor, BCDF, BCGF, BSF-1, Interleukin-4
Cell Type
B Cells, Dendritic Cells, Hematopoietic Stem and Progenitor Cells, Lymphocytes, Monocytes, Myeloid Cells, Neurons, T Cells
Species
Human
Area of Interest
Immunology, Neuroscience, Stem Cell Biology
Molecular Weight
15.1 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant IL-4
Catalog #
78045, 78045.1, 78045.2, 78045.3
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-4
Catalog #
78045, 78045.1, 78045.2, 78045.3
Lot #
All
Language
English

Educational Materials (3)

Brochure
Cytokines, Chemokines and Growth Factors
Brochure
Tools For Your Immunology Research
Wallchart
Human Immune Cytokines

Data and Publications

Data

(A) The biological activity of Human Recombinant IL-4 was tested by its ability to promote the proliferation of TF-1 cells. Cell proliferation was measured after 72 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.16 - 0.24 ng/mL.
(B) 1 μg of Human Recombinant IL-4 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-4 has a predicted molecular mass of 15.1 kDa.

Contact STEMCELL Technologies

Our Customer Service, Sales, and Product and Scientific Support departments in North America are available between 6 am and 5 pm Pacific Time (9 am and 8 pm Eastern Time). One of our representatives will be happy to help you by telephone or email. Please complete the form to contact us by email. A representative will get back to you shortly.
  •  

StemCell Technologies Inc. and affiliates ("STEMCELL Technologies") does not share your email address with third parties. StemCell Technologies Inc. will use your email address to confirm your identity and send you newsletters, transaction-related emails, promotional and customer service emails in accordance with our privacy policy. You can change your email preferences at any time.