Mouse Recombinant IL-13

Interleukin 13

Mouse Recombinant IL-13

Interleukin 13

From: 189 USD
Catalog #
78030_C
Interleukin 13

Overview

Interleukin 13 (IL-13) is a type I cytokine, and signals through type I cytokine receptors to activate JAK/STAT and IRS-1/IRS-2 pathways. IL-13 is produced by T cells and innate lymphoid cells (Pulendran & Artis) and it inhibits production of pro-inflammatory cytokines, prostaglandins, and reactive oxygen and nitrogen species by monocytes and macrophages (Hershey). Unlike human B cells, IL-13 has no effect on mouse B cell development and function. IL-13 promotes eosinophil survival, activation, and recruitment, and also activates mast cells (Hershey). IL-13 regulates gastrointestinal parasite expulsion, airway hyperresponsiveness, allergic inflammation, tissue eosinophilia, goblet cell hyperplasia, intracellular parasitism, tissue remodeling, tumor cell growth, and fibrosis. IL-13 induces hypercontractility of smooth muscles by directly acting on the muscle cells as well as the enteric nerves (Wynn).
Subtype
Cytokines
Alternative Names
Interleukin-13, NC30
Cell Type
B Cells, Hematopoietic Stem and Progenitor Cells, Monocytes
Species
Mouse
Area of Interest
Immunology, Stem Cell Biology
Molecular Weight
12.3 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78030.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78030.1
Lot #
All
Language
English

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

(A) The biological activity of Mouse Recombinant IL-13 was tested by its ability to promote the proliferation of TF-1 cells. Cell proliferation was measured after 66 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 2.3 - 3.4 ng/mL.
(B) 1 ug of Mouse Recombinant IL-13 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IL-13 has a predicted molecular mass of 12.3 kDa.

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