Human Recombinant VEGF-165

Vascular endothelial growth factor

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Vascular endothelial growth factor
From: 468 USD

Overview

Vascular endothelial growth factor (VEGF-165) is a heparin-binding homodimeric glycoprotein involved in embryonic vasculogenesis and angiogenesis. VEGF binds to VEGFR-1 (R1) and VEGFR-2 (R2), and activates Raf/MEK/ERK and PI3K/AKT pathways (Ferrara et al.). It plays an important role in neurogenesis both in vitro and in vivo (Storkebaum et al.). It has neurotrophic effects on neurons of the central nervous system and promotes growth and survival of dopaminergic neurons and astrocytes. VEGF also promotes growth and survival of vascular endothelial cells, monocyte chemotaxis, and colony formation by granulocyte-macrophage progenitor cells (Ferrara et al.).
Alternative Names:
MGC70609, MVCD-1, Vascular endothelial growth factor 2, Vascular endothelial growth factor A, Vascular permeability factor, VEGF­A, VPF
Cell Type:
Mesenchymal Stem and Progenitor Cells; Hematopoietic Stem and Progenitor Cells; Pluripotent Stem Cells; Neural Stem and Progenitor Cells; Endothelial Cells; Angiogenic Cells; Mesoderm, PSC-Derived
Species:
Human
Area of Interest:
Stem Cell Biology; Neuroscience; Angiogenic Cell Research; Endothelial Cell Biology
Molecular Weight:
19.1 kDa monomer; 38.2 kDa dimer
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Human Recombinant VEGF-165 was tested by its ability to promote the proliferation of HUVECs. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 1.7 ng/mL. (B) 4 μg of Human Recombinant VEGF-165 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant VEGF-165 has a predicted molecular mass of 38.2 kDa by non-reducing SDS-PAGE.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.