Human Recombinant BMP-2
Bone morphogenetic protein 2
-
Human Recombinant BMP-2 -
Label for Human Recombinant BMP-2 -
Label for Human Recombinant BMP-2 -
Label for Human Recombinant BMP-2
More Views
Overview
Bone morphogenetic protein 2 (BMP-2) is a member of the transforming growth factor beta (TGF-β) superfamily. BMP-2 is a disulfide-linked homodimer, acts as a ligand for complexes of type I and II BMP receptors, and primarily activates SMAD1/5/8 signaling (Nohe et al.). BMP-2 is a potent differentiation factor and directs human pluripotent stem cells (hPSCs) towards various cell types including extra-embryonic endoderm, mesenchymal cells, and chondrocytes (Pera et al.). Although BMP-2 expression is low in healthy cartilage, its expression is upregulated at the site of cartilage damage (Blaney Davidson et al.). BMP-2 induces bone and cartilage formation in vitro and is able to induce chondrogenesis in human mesenchymal stem cells (Schmitt et al.).
Alternative Names:
BDA2, BMP-2A, BMP2, Bone morphogenetic protein 2A
Cell Type:
Pluripotent Stem Cells; Hematopoietic Stem and Progenitor Cells; Endoderm, PSC-Derived; Mesoderm, PSC-Derived
Species:
Human
Area of Interest:
Neuroscience; Stem Cell Biology; Epithelial Cell Biology
Molecular Weight:
26 kDa
Purity:
≥ 95%
Related Products
-
Activin A -
Basic fibroblast growth factor -
Vascular endothelial growth factor
Scientific Resources
Product Documentation
Document Type
Product Name
Catalog #
Lot #
Language
Product Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Data and Publications
Data
(A) The biological activity of Human Recombinant BMP-2 was tested by its ability to promote alkaline phosphatase production of ATDC-5
cells. Alkaline phosphatase production was measured using a fluorometric assay method. The EC50 is defined as the effective
concentration of the growth factor at which alkaline phosphatase production is at 50% of maximum. The EC50 in the above example is
0.09 μg/mL.
(B) 2 μg of Human Recombinant BMP-2 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized
by Coomassie Blue staining. Human Recombinant BMP-2 has a predicted molecular mass of 26 kDa.
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.