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Human Recombinant IL-15

Interleukin 15

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Interleukin 15
From: 190 USD

Overview

Interleukin 15 (IL-15) is a four-alpha helix bundle cytokine with many similar properties to IL-2, with which it shares components of its receptor. The IL-15 receptor is a heterotrimeric receptor composed of IL-15Ra, the high-affinity receptor for IL-15, as well as IL-2/15Rb (CD122) and common gamma chain (CD132). IL-15 binds to IL-15Rα receptor and can then be presented in trans to IL-2/15Rb and common gamma chain on other cells. Trans-presentation is thought to be the major mechanism by which IL-15-mediated responses occur in mice, although may not be necessary in humans (Castillo et al.). The cytoplasmic domains of IL-2/15Rb and common gamma chain mediate signaling to activate JAK/STAT and PI3K pathways. IL-15 supports the survival and proliferation of naive CD4+ and CD8+ T cells, and promotes homeostasis of memory T cells. IL-15 also promotes the survival and differentiation of NK cells and regulates their cytolytic activity (Ma et al.).
Alternative Names:
IL-T, Interleukin-15
Cell Type:
Hematopoietic Stem and Progenitor Cells; Lymphocytes; NK Cells
Species:
Human
Area of Interest:
Immunology; Stem Cell Biology
Molecular Weight:
12.9 kDa
Purity:
≥ 95%

Scientific Resources

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(3)

Data and Publications

Data

(A) The biological activity of Human Recombinant IL-15 was tested by its ability to promote the proliferation of CTLL-2 cells growing in the presence of other cytokines and stimuli. Cell proliferation was measured after 65 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.13 - 0.19 ng/mL.
(B) 1 ug of Human Recombinant IL-15 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-15 has a predicted molecular mass of 12.9 kDa.

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