A 83-01

Activin/NODAL/TGF-β pathway inhibitor; Inhibits ALK5, ALK4, and ALK7

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Activin/NODAL/TGF-β pathway inhibitor; Inhibits ALK5, ALK4, and ALK7
From: 66 USD

Overview

A 83-01 is a potent inhibitor of activin receptor-like kinase (ALK) including ALK5 (type I transforming growth factor-β receptor), ALK4 (type IB activin receptor), and ALK7 (type I NODAL receptor) with IC50 = 12, 45, and 7.5 nM, respectively (Tojo et al.).

MAINTENANCE AND SELF-RENEWAL
· Facilitates the conversion of epiblast stem cells to the naїve pluripotent state (Zhou et al.; Li et al.).


REPROGRAMMING

· In combination with PD0325901, enables OCT4-mediated reprogramming (Zhu et al.).


DIFFERENTIATION
· Inhibits mesoderm and endoderm specification (Zhang et al.).
· Disrupts epithelial to mesenchymal transition through inhibition of the SMAD signaling pathway (Tojo et al.).
Alternative Names:
Not applicable
CAS Number:
909910-43-6
Chemical Formula:
C₂₅H₁₉N₅S
"
Molecular Weight:
421.5 g/mol
Purity:
≥ 95%
Pathway:
Activin/Nodal/TGFβ
Target:
ALK5

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This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.