MAINTENANCE AND SELF-RENEWAL
· Facilitates the conversion of epiblast stem cells to the naїve pluripotent state (Zhou et al.; Li et al.).
· In combination with PD0325901, enables OCT4-mediated reprogramming (Zhu et al.).
· Inhibits mesoderm and endoderm specification (Zhang et al.).
· Disrupts epithelial to mesenchymal transition through inhibition of the SMAD signaling pathway (Tojo et al.).
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