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Indomethacin

Inhibits COX-1 and COX-2

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Indomethacin

Inhibits COX-1 and COX-2

From: 50 USD
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Inhibits COX-1 and COX-2
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Overview

Indomethacin is a non-steroidal, anti-inflammatory agent that inhibits cyclooxygenase (COX) activity, thereby blocking the production of prostaglandins (Vane et al.). Indomethacin inhibits both COX-1 and COX-2 (IC50 = 0.08 and 0.96 µM for recombinant human COX-1 and COX-2, respectively; Kurumbail et al.).

DIFFERENTIATION
· Activates peroxisome proliferator-activated receptor-γ (PPARγ), a ligand-activated transcription factor known to play a pivotal role in adipogenesis (Lehmann et al.).

· Inhibits chondrogenic differentiation in ATDC5 cells and bone marrow stem cells (Caron et al.).

CANCER RESEARCH

· Inhibits growth of mouse mammary tumors (Fulton).

· Induces apoptosis in prostate and gastric cancer cells (Chiou et al.; Liu et al.).
Cell Type
Adipocytes, Cancer Cells and Cell Lines, Mammary Cells, Monocytes
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Differentiation, Maintenance
Area of Interest
Cancer, Disease Modeling
CAS Number
53-86-1
Chemical Formula
C₁₉H₁₆ClNO₄
Purity
≥ 99%
Pathway
NF-κB
Target
COX-1

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Indomethacin
Catalog #
73942
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Indomethacin
Catalog #
73942
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (3)

Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Small Molecules, Big Impact in Cancer Research
Wallchart
Small Molecules, Big Impact in Cancer Research

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Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.

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